The leaders won 4-0 at Real Mallorca in their first match since the campaign was suspended in March due to the coronavirus pandemic.
Arturo Vidal opened the scoring after just two minutes before Messi set up Martin Braithwaite for his first Barca goal and then Jordi Alba to make the points safe.
Messi then added a fourth in second-half injury time to reach 20 La Liga goals for 2019-20.
The Argentina star is the only player to score 20 or more goals in Spain’s top flight in 12 consecutive seasons.
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Messi’s strong performance against Mallorca also saw his league assist tally this season rise to 14, making him both the top scorer and top assist provider in La Liga this campaign.
Ahead of Barcelona’s return to action, club legend Rivaldo stressed Messi’s workload must be managed carefully, though the 32-year-old did end up playing the full 90 minutes on Saturday.
“Lionel Messi had some physical issues last week, so there’s a lot of discussion about whether he play the whole game for Barcelona in their first game back against Mallorca on Saturday,” Rivaldo told Betfair.
— Goal (@goal) June 13, 2020